In this study, we investigate the causes of homosexuality among African and African-American males, focusing on the interplay of biological, psychological, cultural, and environmental factors. Our research incorporates an interdisciplinary approach, drawing from genetics, neurobiology, sociology, anthropology, and epidemiology, to explore this complex phenomenon. Epidemiological data reveal that homosexuality is highly prevalent in these populations, prompting a closer examination of potential contributing factors. We found evidence suggesting that prenatal hormonal influences and genetic predispositions may play significant roles, alongside cultural and familial dynamics that shape sexual identity formation. Through comprehensive surveys and interviews conducted across six African countries and African-American communities in the United States, our findings highlight a complex relationship between biological, social, and environmental factors.